What is the impact of downstaging in liver transplantation (LT) in patients with HCC outside the Milan criteria?

However, in recent years, strategies for downstaging of HCC in tumors that exceed these criteria have been a reality. Studies demonstrate a 5-year recurrence-free rate of 87%, with a post-liver transplant (LT) recurrence of 8-20%. However, downstaging recommendations in guidelines are still weak. A multicenter study was recently published in JAMA, with the aim of …

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